1348-1350 Europe; Black Death: bubonic plague in addition with typhus, influenza, smallpox etc. led to demographic impacts: in some areas a half or a third of the population may have died; the total loss was a quarter, which equals 40 million fatalities. consequences were: progroms of Jews, burning of witches and hereties violent social conflicts ( i.e English Peasants Revolt,1381 French jacquerie, 1358 with over 30,000 fatalities

1580, Europe: flu epidemic

1665, U.K. London: plague

1793 USA, Philadelphia: Yellow fever, 4000 People died

1832 July - August USA, New York City: Cholera Epidemic, 3,000 people died

1832 October USA, New Orleans: Cholera Epidemic, 4,340 people died

1848 USA, New York City: Cholera Epidemic, more than 5,000 people died

1853 USA, New Orleans: Yellow fever, 7,790 people died

1867 USA, New Orleans: Yellow fever, 3,093 people died

1878 USA, southern States / lower Mississippi Valley: Yellow Fever, 13,000 people died

1916 USA: worst polio epidemic ( infantile paralysis ), 27,363 reported casese, over 7,000 died

1918 March - November USA, worst single U.S. epidemic, influenca, over 500,000 people died

1918, worldwide: Spanish flu epidemic, nearly 22 million people died throughout the world, 12, 5 million in India alone.

1920, India: plague, killing at least two million people

1949 USA polio outbreak, 42,173 cases and 7,000 people died

1994 September 24th. India, western city of Surat: outbreak of pneumonic plague, at least 100 people died